Her-2 Neu Expression in Endometrial Carcinoma
نویسندگان
چکیده
منابع مشابه
Expression of Her-2/neu oncogene in endometrial carcinoma in OMTH
Objective: This retrospective descriptive study to, assess the expression of Her-2 in endometrial carcinoma & to correlate the results with other known clinic pathologic features in Sudanese patients . Material and Methods: Twenty three (23) paraffin-embedded formalin-fixed tissue blocks of endometrial carcinoma were stained by immunoperoxidase stains for Her-2/neu (DAKO, Denmark), collected wi...
متن کاملEffects of ectopic HER-2/neu gene expression on the COX-2/PGE2/P450arom signaling pathway in endometrial carcinoma cells: HER-2/neu gene expression in endometrial carcinoma cells
OBJECTIVES To investigate the role of HER-2/neu-mediated COX-2/P450arom signal in estrogen-dependent endometrial carcinoma. METHODS The recombinant eukaryotic expression vector, pcDNA3.1-HER-2/neu, was constructed and transfect to Ishikawa endometrial carcinoma cells. The expression of COX-2 and P450arom in transfected cells were detected by real-time PCR and western blotting. The levels of e...
متن کاملTargeting HER-2/Neu in serous endometrial cancer: A review
Serous endometrial cancer is a clinically aggressive type of uterine cancer, responsible for a disproportionate incidence of advanced stage disease, recurrences and deaths. Serous endometrial cancers are characterized by alteration of p53, STK15, p16, and HER2. The purpose of this review is to describe the current understanding of the role of the HER-2/neu pathway in the carcinogenesis of serou...
متن کاملEvaluation of HER2/neu Expression in High-Grade Endometrial Carcinoma and Its Clinicopathological Correlation
Background & Objective: Endometrial carcinoma (EC) has been traditionally classified into two distinct categories of low-grade and high-grade. Type I (low grade) EC, which constitutes the majority of cases, is linked to estrogen-related molecular pathways. But type II (high-grade) EC accounts for 10-20% of cases and behaves in an aggressive way. Pathologic and biological featur...
متن کاملExpression of ER, PR, and Her-2/neu in endometrial cancer: a clinicopathological study.
OBJECTIVE To determine any association between expression of estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu and clinicopathological features, including survival, of endometrial carcinoma (EMC) patients. METHODS Samples of formalin-fixed, paraffin-embedded tissue of 108 patients with EMC treated at our institution between January 1994 and December 2007 were immunohistochemic...
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ژورنال
عنوان ژورنال: The Medical Journal of Cairo University
سال: 2018
ISSN: 2536-9806
DOI: 10.21608/mjcu.2018.55033